At the coming of age of in-cell NMR, we provide a detailed overview of its developments and applications in the 20 years that followed its inception. ![]() With the advent of more sensitive NMR hardware and new biotechnological tools, modern in-cell NMR approaches have been established since the early 2000s. Among the existing structural techniques, solution NMR stands out as the only one able to investigate at high resolution the structure and dynamic behavior of macromolecules directly in living cells. To this aim, biological macromolecules should ideally be characterized at atomic resolution directly within the cellular environment. ![]() A detailed knowledge of the complex processes that make cells and organisms alive is fundamental in order to understand diseases and to develop novel drugs and therapeutic treatments.
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